Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment

The greatest obstacle to a cure for HIV is the provirus that integrates into the genome of the infected cell and persists despite antiretroviral therapy. A “shock and kill” approach has been proposed as a strategy for an HIV cure whereby drugs and compounds referred to as latency-reversing agents (L...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: White, Cory H., Beliakova-Bethell, Nadejda, Lada, Steven M., Breen, Michael S., Hurst, Tara P., Spina, Celsa A., Richman, Douglas D., Frater, John, Magiorkinis, Gkikas, Woelk, Christopher H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906534/
https://ncbi.nlm.nih.gov/pubmed/29706951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00603
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