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P2RY1/ALK3-Expressing Cells within the Adult Human Exocrine Pancreas Are BMP-7 Expandable and Exhibit Progenitor-like Characteristics

Treatment of human pancreatic non-endocrine tissue with Bone Morphogenetic Protein 7 (BMP-7) leads to the formation of glucose-responsive β-like cells. Here, we show that BMP-7 acts on extrainsular cells expressing PDX1 and the BMP receptor activin-like kinase 3 (ALK3/BMPR1A). In vitro lineage traci...

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Библиографические подробности
Опубликовано в: :	Cell Rep
Главные авторы:	Qadir, Mirza Muhammad Fahd, Álvarez-Cubela, Silvia, Klein, Dagmar, Lanzoni, Giacomo, García-Santana, Carlos, Montalvo, Abelardo, PlÁceres-Uray, Fabiola, Mazza, Emilia Maria Cristina, Ricordi, Camillo, Inverardi, Luca Alessandro, Pastori, Ricardo Luis, Domínguez-Bendala, Juan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	2018
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5905712/ https://ncbi.nlm.nih.gov/pubmed/29490276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.006
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P2RY1/ALK3-Expressing Cells within the Adult Human Exocrine Pancreas Are BMP-7 Expandable and Exhibit Progenitor-like Characteristics

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