Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase

The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors. About 1/3 of retinoblastoma patients harbor a germline RB1 mutation or deletion, leading to the development of retinoblastom...

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Détails bibliographiques
Publié dans:Stem Cell Res
Auteurs principaux: Tu, Jian, Huo, Zijun, Liu, Mo, Wang, Donghui, Xu, An, Zhou, Ruoji, Zhu, Dandan, Gingold, Julian, Shen, Jingnan, Zhao, Ruiying, Lee, Dung-Fang
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905711/
https://ncbi.nlm.nih.gov/pubmed/29414415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2018.01.021
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