Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8(+) to Treg cell ratio and promoting tumor rejection....

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發表在:Cancer Cell
Main Authors: Arce Vargas, Frederick, Furness, Andrew J.S., Litchfield, Kevin, Joshi, Kroopa, Rosenthal, Rachel, Ghorani, Ehsan, Solomon, Isabelle, Lesko, Marta H., Ruef, Nora, Roddie, Claire, Henry, Jake Y., Spain, Lavinia, Ben Aissa, Assma, Georgiou, Andrew, Wong, Yien Ning Sophia, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Nicol, David, O'Brien, Tim, Mårtensson, Linda, Ljungars, Anne, Teige, Ingrid, Frendéus, Björn, Pule, Martin, Marafioti, Teresa, Gore, Martin, Larkin, James, Turajlic, Samra, Swanton, Charles, Peggs, Karl S., Quezada, Sergio A.
格式: Artigo
語言:Inglês
出版: Cell Press 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904288/
https://ncbi.nlm.nih.gov/pubmed/29576375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.02.010
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