Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression

Knowledge of stromal factors that have a role in the transcriptional regulation of metabolic pathways aside from c-Myc is fundamental to improvements in lymphoma therapy. Using a MYC-inducible human B-cell line, we observed the cooperative activation of STAT3 and NF-κB by IL10 and CpG stimulation. W...

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Publicat a:Nat Commun
Autors principals: Feist, Maren, Schwarzfischer, Philipp, Heinrich, Paul, Sun, Xueni, Kemper, Judith, von Bonin, Frederike, Perez-Rubio, Paula, Taruttis, Franziska, Rehberg, Thorsten, Dettmer, Katja, Gronwald, Wolfram, Reinders, Jörg, Engelmann, Julia C., Dudek, Jan, Klapper, Wolfram, Trümper, Lorenz, Spang, Rainer, Oefner, Peter J., Kube, Dieter
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904148/
https://ncbi.nlm.nih.gov/pubmed/29666362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03803-x
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