Ascorbic acid induces global epigenetic reprogramming to promote meiotic maturation and developmental competence of porcine oocytes

L-ascorbic acid (Vitamin C) can enhance the meiotic maturation and developmental competence of porcine oocytes, but the underlying molecular mechanism remains obscure. Here we show the role of ascorbic acid in regulating epigenetic status of both nucleic acids and chromatin to promote oocyte maturat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Yu, Xiao-Xia, Liu, Yun-Hua, Liu, Xiao-Man, Wang, Pei-Chao, Liu, Shuai, Miao, Jia-Kun, Du, Zhi-Qiang, Yang, Cai-Xia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904140/
https://ncbi.nlm.nih.gov/pubmed/29666467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24395-y
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