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Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

The inwardly rectifying K(+) channel K(ir)4.1 is broadly expressed by CNS glia and deficits in K(ir)4.1 lead to seizures and myelin vacuolization. However, the role of oligodendrocyte K(ir)4.1 channels in controlling myelination and K(+) clearance in white matter has not been defined. Here, we show...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Larson, Valerie A, Mironova, Yevgeniya, Vanderpool, Kimberly G, Waisman, Ari, Rash, John E, Agarwal, Amit, Bergles, Dwight E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903864/
https://ncbi.nlm.nih.gov/pubmed/29596047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34829
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