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An incoherent feedforward loop facilitates adaptive tuning of gene expression

We studied adaptive evolution of gene expression using long-term experimental evolution of Saccharomyces cerevisiae in ammonium-limited chemostats. We found repeated selection for non-synonymous variation in the DNA binding domain of the transcriptional activator, GAT1, which functions with the repr...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hong, Jungeui, Brandt, Nathan, Abdul-Rahman, Farah, Yang, Ally, Hughes, Tim, Gresham, David
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903863/
https://ncbi.nlm.nih.gov/pubmed/29620523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32323
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