VEGF-C promotes the development of lymphatics in bone and bone loss

Patients with Gorham-Stout disease (GSD) have lymphatic vessels in their bones and their bones gradually disappear. Here, we report that mice that overexpress VEGF-C in bone exhibit a phenotype that resembles GSD. To drive VEGF-C expression in bone, we generated Osx-tTA;TetO-Vegfc double-transgenic...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Hominick, Devon, Silva, Asitha, Khurana, Noor, Liu, Ying, Dechow, Paul C, Feng, Jian Q, Pytowski, Bronislaw, Rutkowski, Joseph M, Alitalo, Kari, Dellinger, Michael T
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903859/
https://ncbi.nlm.nih.gov/pubmed/29620526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34323
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