Paris Polyphylla-Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression

OBJECTIVES: Paris polyphylla var. yunnanensis (PPVY), a Chinese herb, has long been used for cancer treatment, and its steroidal saponins are suggested to exert an anti-tumor activity, however, the underlying mechanism is incompletely understood and their effect on bladder cancer (BC) remains unknow...

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Dettagli Bibliografici
Pubblicato in:Curr Urol
Autori principali: Guo, Yanxia, Liu, Zhiyong, Li, Kailin, Cao, Guangshang, Sun, Chao, Cheng, Guanghui, Zhang, Denglu, Peng, Wei, Liu, Jiaxin, Qi, Yuanfu, Zhang, Lu, Wang, Peng, Chen, Yuan, Lin, Zhaomin, Guan, Yong, Zhang, Jianye, Wen, Jiliang, Wang, Fang, Kong, Feng, Xu, Dawei, Zhao, Shengtian
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2018
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903466/
https://ncbi.nlm.nih.gov/pubmed/29692692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000447207
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