Pharmacokinetic/pharmacodynamic drug–drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs

AIMS: Avatrombopag, a thrombopoietin receptor agonist, is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A. We assessed three drug–drug interactions of avatrombopag as a victim with dual or selective CYP2C9/3A inhibitors and inducers. METHODS: This was a three‐part, open‐label study. Forty‐eight h...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Nomoto, Maiko, Zamora, Cynthia A., Schuck, Edgar, Boyd, Peter, Chang, Min‐Kun, Aluri, Jagadeesh, Siu, Y. Amy, Lai, W. George, Yasuda, Sanae, Ferry, Jim, Rege, Bhaskar
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Drug Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903264/
https://ncbi.nlm.nih.gov/pubmed/29341245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13517
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