An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation

Different immune activation states require distinct metabolic features and activities in immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages; however, the precise role of t...

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Gardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Carroll, Richard G., Zasłona, Zbigniew, Galván-Peña, Silvia, Koppe, Emma L., Sévin, Daniel C., Angiari, Stefano, Triantafilou, Martha, Triantafilou, Kathy, Modis, Louise K., O'Neill, Luke A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900750/
https://ncbi.nlm.nih.gov/pubmed/29463677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001921
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