The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression

RATIONALE: Depression is a leading cause of disease burden and disability for older adults; thus, prevention is a priority. Biologic and observational data support potential mental health benefits of vitamin D and omega-3 fatty acids; however, it is unclear whether these supplements can prevent late...

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Pubblicato in:Contemp Clin Trials
Autori principali: Okereke, Olivia I., Reynolds, Charles F., Mischoulon, David, Chang, Grace, Cook, Nancy R., Copeland, Trisha, Friedenberg, Georgina, Buring, Julie E., Manson, JoAnn E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899680/
https://ncbi.nlm.nih.gov/pubmed/29526608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2018.02.017
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