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Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus
Stress-related alterations in brain-derived neurotrophic factor (BDNF) expression, a neurotrophin that plays a key role in synaptic plasticity, are believed to contribute to the pathophysiology of depression. Here, we show that in a chronic mild stress (CMS) model of depression the Gαi1 and Gαi3 sub...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899481/ https://ncbi.nlm.nih.gov/pubmed/29507199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722493115 |
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