Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus

Stress-related alterations in brain-derived neurotrophic factor (BDNF) expression, a neurotrophin that plays a key role in synaptic plasticity, are believed to contribute to the pathophysiology of depression. Here, we show that in a chronic mild stress (CMS) model of depression the Gαi1 and Gαi3 sub...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Marshall, John, Zhou, Xiao-zhong, Chen, Gang, Yang, Su-qing, Li, Ya, Wang, Yin, Zhang, Zhi-qing, Jiang, Qin, Birnbaumer, Lutz, Cao, Cong
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899481/
https://ncbi.nlm.nih.gov/pubmed/29507199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722493115
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