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hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification

The aim of the study was to analyze the effect of hTERT gene knockdown in HNSCC cells by using novel in vitro models of head and neck cancer (HNSCC), as well as improving its personalized therapy. To obtain the most efficient knockdown siRNA, shRNA-bearing lentiviral vectors were used. The efficienc...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Barczak, Wojciech, Sobecka, Agnieszka, Golusinski, Pawel, Masternak, Michal M., Rubis, Blazej, Suchorska, Wiktoria M., Golusinski, Wojciech
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899166/
https://ncbi.nlm.nih.gov/pubmed/29654294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24503-y
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