Piperazinyl fragment improves anticancer activity of Triapine

A new class of TSCs containing piperazine (piperazinylogs) of Triapine, was designed to fulfill the di-substitution pattern at the TSCs N4 position, which is a crucial prerequisite for the high activity of the previously obtained TSC compounds–DpC and Dp44mT. We tested the important physicochemical...

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Udgivet i:PLoS One
Main Authors: Rejmund, Marta, Mrozek-Wilczkiewicz, Anna, Malarz, Katarzyna, Pyrkosz-Bulska, Monika, Gajcy, Kamila, Sajewicz, Mieczyslaw, Musiol, Robert, Polanski, Jaroslaw
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898707/
https://ncbi.nlm.nih.gov/pubmed/29652894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188767
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