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Sustained analgesic effect of clonidine co-polymer depot in a porcine incisional pain model
BACKGROUND: Previous research suggests that the α(2) adrenergic agonist clonidine, a centrally acting analgesic and antihypertensive, may also have direct effects on peripheral pain generators. However, aqueous injections are limited by rapid systemic absorption leading to off target effects and a b...
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| Publicado no: | J Pain Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5898591/ https://ncbi.nlm.nih.gov/pubmed/29670396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S157018 |
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