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Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement

BACKGROUND: Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the component of gastric duodenal contents, has been recognised as a carcinogen. BA-induce...

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Библиографические подробности
Опубликовано в: :BMC Cancer
Главные авторы: Tan, Sang-Nee, Sim, Sai-Peng
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898073/
https://ncbi.nlm.nih.gov/pubmed/29649994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4327-4
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