Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models

In addition to their canonical roles in regulating cell cycle transition and transcription, cyclin-dependent kinases (CDKs) have been shown to coordinate DNA damage response pathways, suggesting a rational pairing of CDK inhibitors with genotoxic chemotherapeutic agents in the treatment of human mal...

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Publicat a:Signal Transduct Target Ther
Autors principals: Syn, Nicholas L., Lim, Pei Li, Kong, Li Ren, Wang, Lingzhi, Wong, Andrea Li-Ann, Lim, Chwee Ming, Loh, Thomas Kwok Seng, Siemeister, Gerhard, Goh, Boon Cher, Hsieh, Wen-Son
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897350/
https://ncbi.nlm.nih.gov/pubmed/29666673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-018-0010-0
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