GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease

We report that half striatal cholinergic interneurons are dual transmitter cholinergic and GABAergic interneurons (CGINs) expressing ChAT, GAD65, Lhx7, and Lhx6 mRNAs, labeled with GAD and VGAT, generating monosynaptic dual cholinergic/GABAergic currents and an inhibitory pause response. Dopamine de...

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Publicat a:Nat Commun
Autors principals: Lozovaya, N., Eftekhari, S., Cloarec, R., Gouty-Colomer, L. A., Dufour, A., Riffault, B., Billon-Grand, M., Pons-Bennaceur, A., Oumar, N., Burnashev, N., Ben-Ari, Y., Hammond, C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897332/
https://ncbi.nlm.nih.gov/pubmed/29651049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03802-y
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