Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection

The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and thiazole scaffolds and then tested in a screeening cascade for MMP inhibition. W...

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Vydáno v:Front Pharmacol
Hlavní autoři: Bencsik, Péter, Kupai, Krisztina, Görbe, Anikó, Kenyeres, Éva, Varga, Zoltán V., Pálóczi, János, Gáspár, Renáta, Kovács, László, Weber, Lutz, Takács, Ferenc, Hajdú, István, Fabó, Gabriella, Cseh, Sándor, Barna, László, Csont, Tamás, Csonka, Csaba, Dormán, György, Ferdinandy, Péter
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896266/
https://ncbi.nlm.nih.gov/pubmed/29674965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00296
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