Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several distinctive features of ubiquitin recognition and cataly...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Kwasna, Dominika, Abdul Rehman, Syed Arif, Natarajan, Jayaprakash, Matthews, Stephen, Madden, Ross, De Cesare, Virginia, Weidlich, Simone, Virdee, Satpal, Ahel, Ivan, Gibbs-Seymour, Ian, Kulathu, Yogesh
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896202/
https://ncbi.nlm.nih.gov/pubmed/29576527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.02.023
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