Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4

NADPH oxidases (Nox enzymes) are critical mediators of both physiologic and pathophysiologic processes. Nox enzymes catalyze NADPH-dependent generation of reactive oxygen species (ROS), including superoxide and hydrogen peroxide. Until recently, Nox4 was proposed to be involved exclusively in normal...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Xu, Qian, Kulkarni, Amol A., Meleveetil, Sajith, Hussein, Dilbi, Brown, David, Güner, Osman F., Reddy, M. Damoder, Watkins, E. Blake, Lassègue, Bernard, Griendling, Kathy K., Bowen, J. Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895456/
https://ncbi.nlm.nih.gov/pubmed/29426628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.12.023
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