Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers

BACKGROUND: While a number of autosomal dominant and autosomal recessive cancer syndromes have an associated spectrum of cancers, the prevalence and variety of cancer predisposition mutations in patients with multiple primary cancers have not been extensively investigated. An understanding of the va...

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Veröffentlicht in:PLoS One
Hauptverfasser: Pritchard, Antonia L., Johansson, Peter A., Nathan, Vaishnavi, Howlie, Madeleine, Symmons, Judith, Palmer, Jane M., Hayward, Nicholas K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894988/
https://ncbi.nlm.nih.gov/pubmed/29641532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194098
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