Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology

Previous studies demonstrated that selenium in the form of sodium selenate reduces neurofibrillary tangle formation in Alzheimer’s disease models. Hyperphosphorylation of tau, which leads to formation of neurofibrillary tangles in Alzheimer’s disease, is increased by endoplasmic reticulum (ER) stres...

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發表在:J Alzheimers Dis
Main Authors: Rueli, Rachel H.L.H., Torres, Daniel J., Dewing, Andrea S.T., Kiyohara, Arlene C., Barayuga, Stephanie M., Bellinger, Miyoko T., Uyehara-Lock, Jane H., White, Lon R., Moreira, Paula I., Berry, Marla J., Perry, George, Bellinger, Frederick P.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893862/
https://ncbi.nlm.nih.gov/pubmed/27802219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-151208
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