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Disulfiram-based disulfides as narrow-spectrum antibacterial agents

Sixteen disulfides derived from disulfiram (Antabuse(™)) were evaluated as antibacterial agents. Derivatives with hydrocarbon chains of seven and eight carbons in length exhibited antibacterial activity against Gram-positive Staphylococcus, Streptococcus, Enterococcus, Bacillus, and Listeria spp. A...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Sheppard, Jordan G., Frazier, Keely R., Saralkar, Pushkar, Hossain, Mohammad F., Geldenhuys, Werner J., Long, Timothy E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893419/
https://ncbi.nlm.nih.gov/pubmed/29571571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.023
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