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DNA methylation loss in late-replicating domains is linked to mitotic cell division
DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-associated, late-replicating regions termed Partially Methylated Domains (PMDs). We profiled 39 diverse primary tumors and 8 matched adjacent tissues using Whole-Genome Bisulfite Sequencing (WGBS), and analyzed them al...
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| Publicado no: | Nat Genet |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5893360/ https://ncbi.nlm.nih.gov/pubmed/29610480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0073-4 |
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