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Structures of the Mycobacterium tuberculosis GlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition

The crystal structures of native class II fructose-1,6-bisphosphatase (FBPaseII) from Mycobacterium tuberculosis at 2.6 Å resolution and two active-site protein variants are presented. The variants were complexed with the reaction product fructose 6-phosphate (F6P). The Thr84Ala mutant is inactive,...

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Dettagli Bibliografici
Pubblicato in:Acta Crystallogr D Struct Biol
Autori principali: Wolf, Nina M., Gutka, Hiten J., Movahedzadeh, Farahnaz, Abad-Zapatero, Celerino
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892879/
https://ncbi.nlm.nih.gov/pubmed/29652259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798318002838
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