Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma

BACKGROUND: Cisplatin is a key drug for treating lung adenocarcinoma, and its sensitivity to cisplatin is directly related to prognosis. We aimed to reveal the roles of genes related to glutathione synthesis (glutamate-cysteine ligase catalytic subunit, GCLC) and cystine uptake (cystine/glutamate tr...

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Détails bibliographiques
Publié dans:Jpn J Clin Oncol
Auteurs principaux: Hiyama, Noriko, Ando, Takahiro, Maemura, Keita, Sakatani, Toshio, Amano, Yosuke, Watanabe, Kousuke, Kage, Hidenori, Yatomi, Yutaka, Nagase, Takahide, Nakajima, Jun, Takai, Daiya
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892860/
https://ncbi.nlm.nih.gov/pubmed/29474642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jjco/hyy013
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