Development, validation and utilization of a highly sensitive LC-MS/MS method for quantification of levonorgestrel released from a subdermal implant in human plasma

Levonorgestrel (LNG) is a synthetic progestin that is available in oral contraceptive tablets, a subdermal implant, and an intrauterine system for contraception. LNG pharmacokinetics are a pivotal determinant of contraceptive efficacy and essential in assessing drug-drug interactions influencing LNG...

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Gepubliceerd in:J Chromatogr B Analyt Technol Biomed Life Sci
Hoofdauteurs: Cirrincione, Lauren R., Penchala, Sujan Dilly, Scarsi, Kimberly K., Podany, Anthony T., Winchester, Lee C., Back, David J., Khoo, Saye H., Fletcher, Courtney V., Siccardi, Marco, Else, Laura J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892837/
https://ncbi.nlm.nih.gov/pubmed/29579732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2018.03.023
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