L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis

Ethanol causes fetal alcohol spectrum disorders (FASDs) partly by inhibiting cell adhesion mediated by the L1 neural cell adhesion molecule. Ethanol interacts with an alcohol binding pocket in the L1 extracellular domain (ECD), and dephosphorylation of S1248 in the L1 cytoplasmic domain (CD) renders...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Dou, Xiaowei, Menkari, Carrie, Mitsuyama, Rei, Foroud, Tatiana, Wetherill, Leah, Hammond, Peter, Suttie, Michael, Chen, Xiaopan, Chen, Shao-Yu, Charness, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892731/
https://ncbi.nlm.nih.gov/pubmed/29109170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700970
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