Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells

BACKGROUND: CD19-chimericantigen receptor (CAR) modified T cells (CD19-CAR T cells) have been well documented to possess potent anti-tumor properties against CD19-expressingleukemia cells. As a traditional medicine, metformin has been widely used to treat type II diabetes mellitus and more recently...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Mu, Qian, Jiang, Miao, Zhang, Yuzhu, Wu, Fei, Li, Hui, Zhang, Wen, Wang, Fang, Liu, Jiang, Li, Liang, Wang, Dongshan, Wang, Wenjuan, Li, Shiwu, Song, Haibo, Tang, Dongqi
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892609/
https://ncbi.nlm.nih.gov/pubmed/29662316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S154853
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