Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation

In response to the microenvironment, microglia may polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype, conferring neuroprotection. Betulinic acid (BA) is a naturally pentacyclic triterpenoid with considerable anti-inflammatory prop...

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Bibliographic Details
Published in:Front Mol Neurosci
Main Authors: Li, Chuwen, Zhang, Chao, Zhou, Hefeng, Feng, Yu, Tang, Fan, Hoi, Maggie P. M., He, Chengwei, Ma, Dan, Zhao, Chao, Lee, Simon M. Y.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891622/
https://ncbi.nlm.nih.gov/pubmed/29666569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00098
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