Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation

In response to the microenvironment, microglia may polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype, conferring neuroprotection. Betulinic acid (BA) is a naturally pentacyclic triterpenoid with considerable anti-inflammatory prop...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Mol Neurosci
Prif Awduron: Li, Chuwen, Zhang, Chao, Zhou, Hefeng, Feng, Yu, Tang, Fan, Hoi, Maggie P. M., He, Chengwei, Ma, Dan, Zhao, Chao, Lee, Simon M. Y.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891622/
https://ncbi.nlm.nih.gov/pubmed/29666569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00098
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg