Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of bile salts from their precursors in primary human, monkey, dog, rat, and mouse hepatocytes in suspen...

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Detalhes bibliográficos
Publicado no:Chem Biol Interact
Main Authors: Zhang, Jie, He, Kan, Cai, Lining, Chen, Yu-Chuan, Yang, Yifan, Shi, Qin, Woolf, Thomas F., Ge, Weigong, Guo, Lei, Borlak, Jürgen, Tong, Weida
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891329/
https://ncbi.nlm.nih.gov/pubmed/27000539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2016.03.019
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