Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal and tumour seeding capacity. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse. Salinomycin operates as a selective agent against CSCs through mecha...

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Pubblicato in:Nat Chem
Autori principali: Mai, Trang Thi, Hamaï, Ahmed, Hienzsch, Antje, Cañeque, Tatiana, Müller, Sebastian, Wicinski, Julien, Cabaud, Olivier, Leroy, Christine, David, Amandine, Acevedo, Verónica, Ryo, Akihide, Ginestier, Christophe, Birnbaum, Daniel, Charafe-Jauffret, Emmanuelle, Codogno, Patrice, Mehrpour, Maryam, Rodriguez, Raphaël
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890907/
https://ncbi.nlm.nih.gov/pubmed/28937680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2778
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