Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation

Green tea (Camellia sinensis) is a popular beverage worldwide, raising concern for adverse interactions when co-consumed with conventional drugs. Like many botanical natural products, green tea contains numerous polyphenolic constituents that undergo extensive glucuronidation. As such, the UDP-glucu...

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Publicado no:Drug Metab Dispos
Main Authors: Tian, Dan-Dan, Kellogg, Joshua J., Okut, Neşe, Oberlies, Nicholas H., Cech, Nadja B., Shen, Danny D., McCune, Jeannine S., Paine, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890833/
https://ncbi.nlm.nih.gov/pubmed/29467215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.079491
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