Micafungin alters the amino acid, nucleic acid and central carbon metabolism of Candida albicans at subinhibitory concentrations: novel insights into mechanisms of action

Background: Echinocandins are an important class of antifungal agents in the treatment of invasive candidiasis. However, little is known about the metabolomic effects of echinocandins on Candida. We therefore performed LC–high-resolution MS (LC-HRMS)-based metabolomics profiling of the response of C...

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Bibliographic Details
Published in:J Antimicrob Chemother
Main Authors: Katragkou, Aspasia, Williams, Michael, Sternberg, Sandi, Pantazatos, Dennis, Roilides, Emmanuel, Walsh, Thomas J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890779/
https://ncbi.nlm.nih.gov/pubmed/28039272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw478
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