Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata

BACKGROUND: Echinocandins are recommended as first-line therapy against Candida glabrata infections, although increased resistance to this class has been reported worldwide and they are currently only available for parenteral administration. SCY-078 is an investigational glucan synthase inhibitor th...

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Dettagli Bibliografici
Pubblicato in:J Antimicrob Chemother
Autori principali: Wiederhold, Nathan P, Najvar, Laura K, Jaramillo, Rosie, Olivo, Marcos, Pizzini, Jason, Catano, Gabriel, Patterson, Thomas F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890676/
https://ncbi.nlm.nih.gov/pubmed/29177447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx422
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