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Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli
BACKGROUND: Ciprofloxacin, a fluoroquinolone, targets two essential bacterial enzymes, DNA gyrase and topoisomerase IV. Plasmid-borne qnr genes, encoding proteins that protect DNA gyrase and topoisomerase IV from inhibition by fluoroquinolones, contribute to resistance development. However, the pres...
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| Pubblicato in: | J Antimicrob Chemother |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5890660/ https://ncbi.nlm.nih.gov/pubmed/29106520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx375 |
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