Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells

Clinical and fundamental research suggest that altered calcium and cAMP signaling might be the most proximal events in ADPKD pathogenesis. Cells from ADPKD cysts have a reduced resting cytosolic calcium [Ca(2+)](i) and increased cAMP levels. CaSR plays an essential role in regulating calcium homeost...

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Publicado no:Sci Rep
Main Authors: Di Mise, Annarita, Tamma, Grazia, Ranieri, Marianna, Centrone, Mariangela, van den Heuvel, Lambertus, Mekahli, Djalila, Levtchenko, Elena N., Valenti, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890283/
https://ncbi.nlm.nih.gov/pubmed/29632324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23732-5
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