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Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients
CTLA-4 inhibition produces durable T cell–driven antitumor responses, but understanding which patients achieve a long-term benefit remains unclear. Deep sequencing of rearranged T cell receptor β (TCRβ) genes can monitor the effects of CTLA-4 inhibition and potentially identify patients with long-te...
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| Publicado no: | Oncoimmunology |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5889199/ https://ncbi.nlm.nih.gov/pubmed/29632706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.956016 |
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