The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [(11)C]Cimbi-36 labeled in two positions

[(11)C]Cimbi-36, a 5-HT(2A) receptor agonist PET radioligand, contains three methoxy groups amenable to [(11)C]-labeling. In pigs, [(11)C]Cimbi-36 yields a polar (M1) and a less polar (M2) radiometabolite fraction, while changing the labeling to [(11)C]Cimbi-36_5 yields only the M1 fraction. We inve...

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Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Johansen, Annette, Hansen, Hanne D, Svarer, Claus, Lehel, Szabolcs, Leth-Petersen, Sebastian, Kristensen, Jesper L, Gillings, Nic, Knudsen, Gitte M
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2017
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888860/
https://ncbi.nlm.nih.gov/pubmed/29215308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17746179
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