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Are Nonsense Alleles of Drosophila melanogaster Genes under Any Selection?

A gene which carries a bona fide loss-of-function mutation effectively becomes a functionless pseudogene, free from selective constraint. However, there is a number of molecular mechanisms that may lead to at least a partial preservation of the function of genes carrying even drastic alleles. We per...

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Bibliografske podrobnosti
izdano v:Genome Biol Evol
Main Authors: Potapova, Nadezhda A, Andrianova, Maria A, Bazykin, Georgii A, Kondrashov, Alexey S
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888714/
https://ncbi.nlm.nih.gov/pubmed/29425311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evy032
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