Noncanonical substrate preference of lambda exonuclease for 5′-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction

Lambda exonuclease (λ exo) plays an important role in the resection of DNA ends for DNA repair. Currently, it is also a widely used enzymatic tool in genetic engineering, DNA-binding protein mapping, nanopore sequencing and biosensing. Herein, we disclose two noncanonical properties of this enzyme a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Wu, Tongbo, Yang, Yufei, Chen, Wei, Wang, Jiayu, Yang, Ziyu, Wang, Shenlin, Xiao, Xianjin, Li, Mengyuan, Zhao, Meiping
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Nucleic Acid Enzymes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888420/
https://ncbi.nlm.nih.gov/pubmed/29490081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky154
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