Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase

Pathological conditions impairing functions of mitochondria often lead to compensatory upregulation of the mitochondrial DNA (mtDNA) replisome machinery, and the replicative DNA helicase appears to be a key factor in regulating mtDNA copy number. Moreover, mtDNA helicase mutations have been associat...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Ciesielski, Grzegorz L, Nadalutti, Cristina A, Oliveira, Marcos T, Jacobs, Howard T, Griffith, Jack D, Kaguni, Laurie S
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887560/
https://ncbi.nlm.nih.gov/pubmed/29432582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky094
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