Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment

Tumour necrosis factor (TNF) is produced by primary human macrophages in response to stimulation by exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs) via Toll-like receptor (TLR) signalling. However, uncontrolled TNF production can b...

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Veröffentlicht in:Biochem Biophys Res Commun
Hauptverfasser: Page, Theresa H., Urbaniak, Anna M., Espirito Santo, Ana I., Danks, Lynett, Smallie, Timothy, Williams, Lynn M., Horwood, Nicole J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887515/
https://ncbi.nlm.nih.gov/pubmed/29567473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.03.140
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