Complete intracranial response to talimogene laherparepvec (T-Vec), pembrolizumab and whole brain radiotherapy in a patient with melanoma brain metastases refractory to dual checkpoint-inhibition

BACKGROUND: Immunotherapy, in particular checkpoint blockade, has changed the clinical landscape of metastatic melanoma. Nonetheless, the majority of patients will either be primary refractory or progress over follow up. Management of patients progressing on first-line immunotherapy remains challeng...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Blake, Zoë, Marks, Douglas K., Gartrell, Robyn D., Hart, Thomas, Horton, Patti, Cheng, Simon K., Taback, Bret, Horst, Basil A., Saenger, Yvonne M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887256/
https://ncbi.nlm.nih.gov/pubmed/29622046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0338-6
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