Quantitative assessment of timing, efficiency, specificity and genetic mosaicism of CRISPR/Cas9-mediated gene editing of hemoglobin beta gene in rhesus monkey embryos

Gene editing technologies offer new options for developing novel biomedical research models and for gene and stem cell based therapies. However, applications in many species demand high efficiencies, specificity, and a thorough understanding of likely editing outcomes. To date, overall efficiencies,...

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Detaylı Bibliyografya
Yayımlandı:Hum Mol Genet
Asıl Yazarlar: Midic, Uros, Hung, Pei-Hsuan, Vincent, Kailey A., Goheen, Benjamin, Schupp, Patrick G., Chen, Diane D., Bauer, Daniel E., VandeVoort, Catherine A., Latham, Keith E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886216/
https://ncbi.nlm.nih.gov/pubmed/28444193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx154
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