NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis of brown-fat-specific open chromatin regions....

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Publicat a:Nat Cell Biol
Autors principals: Hiraike, Yuta, Waki, Hironori, Yu, Jing, Nakamura, Masahiro, Miyake, Kana, Nagano, Gaku, Nakaki, Ryo, Suzuki, Ken, Kobayashi, Hirofumi, Yamamoto, Shogo, Sun, Wei, Aoyama, Tomohisa, Hirota, Yusuke, Ohno, Haruya, Oki, Kenji, Yoneda, Masayasu, White, Andrew P., Tseng, Yu-Hua, Cypess, Aaron M., Larsen, Therese J., Jespersen, Naja Z., Scheele, Camilla, Tsutsumi, Shuichi, Aburatani, Hiroyuki, Yamauchi, Toshimasa, Kadowaki, Takashi
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885759/
https://ncbi.nlm.nih.gov/pubmed/28812581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3590
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