Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial

IMPORTANCE: The role of the apolipoprotein E (APOE) ε4 allele as an effect modifier in lifestyle interventions to prevent cognitive impairment is still unclear. OBJECTIVE: To examine whether the APOE ε4 allele modifies the previously reported significant cognitive benefits of a multidomain lifestyle...

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Vydáno v:JAMA Neurol
Hlavní autoři: Solomon, Alina, Turunen, Heidi, Ngandu, Tiia, Peltonen, Markku, Levälahti, Esko, Helisalmi, Seppo, Antikainen, Riitta, Bäckman, Lars, Hänninen, Tuomo, Jula, Antti, Laatikainen, Tiina, Lehtisalo, Jenni, Lindström, Jaana, Paajanen, Teemu, Pajala, Satu, Stigsdotter-Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, Kivipelto, Miia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2018
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885273/
https://ncbi.nlm.nih.gov/pubmed/29356827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2017.4365
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